East Anglia East Anglian Collie Association
Established 1957
© East Anglian Collie Association 2013/17
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East Anglian Collie Association Logo DNA Tests chromosome

DNA or deoxyribonucleic acid is carried in the nucleus of every living cell and contains the genetic material used in the development and functioning of all organisms.

DNA was first discovered in 1869 by Swiss scientist Friedrich Miescher but
it was not until 1953 that James Watson and Francis Crick discovered its actual structure. They discovered that DNA is comprised of two strands known as chromosomes, twisted in a spiral or helix, with cross pieces like
a twisted ladder. In 1962 Watson and Crick received the Nobel Prize for
their work though it was not until 1966 that they managed to crack the genetic code.

Paired chromosomes contain DNA in a double helix structure and contain thousands of paired genes along their lengths. A gene is a molecular unit
of heredity of a living organism, and they hold the information to build and maintain the cells and pass on genetic traits to the offspring
eg eye colour, number of limbs, blood group, hair colour etc.

When the cells of the body duplicate, the DNA also replicates itself, though not always accurately. When errors occur they are known as mutations and these can give rise to either inherited diseases or physical and mental abnormalities.

The advantage of a DNA test for a particular health issue, is that it provides an accurate genetic result rather than the ‘hit and miss’ results of clinical tests. Genetic tests are fantastic tools for breeders to make use of and Collie breeders are now fortunate in having DNA tests for:

Gene Mutations Genetic Tests

caused by a Growth Hormone deficiency, which may be inherited, with affected dogs usually appearing normal at birth, but showing evidence of failure to grow by two to three months of age. The condition affects all breeds and cases have been diagnosed in our Collies — Genetic Testing Laboratories Laboklin & Animal DNA Diagnostics

Degenerative Myelopathy, a non-breed-specific progressive condition which causes a loss of coordination (ataxia) in the hind limbs in later life, and which is known to affect certain Collie lines — Genetic Testing Laboratories Laboklin, Animal Genetics & Antagene

DM

Multi-Drug Resistance, a defect in the Collie’s ability to pump out certain drug toxins from its body — Genetic Testing Laboratories Laboklin, Genomia, Animal Genetics, Antagene & eurovetgene

MDR1

the early-onset form of Generalised Progressive Retinal Atrophy (not seen in wholly European Collies but can afflict those of American descent) —
Genetic Testing Laboratory Optigen & eurovetgene

the Choroidal Hypoplasia (CH) aspect of Collie Eye Anomaly — Genetic Testing Laboratories Optigen &

         animal genetics

CEA

Knowing the genetic health status of a given dog or bitch is hugely beneficial for breeders as it enables us to estimate the
health status of our
puppies as follows:


Clear to clear = 100% clears

Clear to carrier = 50% clears &     50% carriers

Clear to affected = 100% carriers

Carrier to carrier = 25% clears,    50% carriers & 25% affected

Carrier to affected = 50%
 carriers & 50% affected

Affected to affected
= 100% affected                                                  affected




enlarged DNA structure Enlarged DNA 
Structure
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Laboklin, Optigen & Animal Genetics  have official schemes whereby test results are submitted directly  to the Kennel Club if requested on
the order form.

Breeders can also submit copies of test certificates directly to Nick Sutton at the KC.



In addition to providing genetic tests, Laboklin also provides a list of Suspect Drugs on its web-site.

It is now compulsory
for all dogs to be microchipped.  


DNA Profiling

The Kennel Club is considering making DNA profiling
mandatory, as a means of confirming the parentage of a particular animal.

Breeders can have litters from dual matings without the prior approval of the KC. puppies can be registered providing they have first been DNA profiled to determine their parentage.

The kennel club accepts that a two-sire mating replicates natural behaviour and has
the advantage of producing
two litters in one gestation/whelping, so aiding the expansion of the gene pool more rapidly.

CEA database of genetically tested Rough Collies

WelcomeMembershipEventsThe Collie

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  breed standardcollie care health

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  dna tests • kc/bva tests general health issues

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